What's Up Panimanishi is a ZEE5 Telugu Original series starring Dhanya Balakrishna, Rakendu Mouli, Abhirami Iyer and Praveen Kumar M. The story revolves around Jessi, an ultra-modern and tech savvy maid, who is an integral part of her employer Natraj’s life. Things get complicated when Natraj’s newly-wed wife feels jealous of Jessi’s tech savvy skills and her chemistry with Natraj.