Researchers Come Up With New And Promising Strategy To Target Brain Tumours

A potentially promising strategy has been discovered by Massachusetts General Hospital to target brain tumour found in younger adults aged 18 to 45 years.

ZEE5 Web Desk

July 2, 2020

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Led by investigators at the Massachusetts General Hospital, a team of researchers have come up with a way to treat isocitrate dehydrogenase (IDH) genes, which happen to be the most common brain tumours diagnosed in young adults. Their study has been published in Cancer Discovery, a journal of the American Association for Cancer Research (AACR). Prior work by the group had revealed that that IDH mutant gliomas have a metabolic weakness that makes them susceptible to treatments that lower NAD+ levels. They had also found that chemotherapy activates an enzyme that stimulates NAD+ molecules to join together to make PAR (poly ADP-ribose), which is a key DNA damage signal.

Dr Daniel Cahill, a Neurosurgical Oncologist at Mass General and an Associate Professor of Neurosurgery at Harvard Medical School, said, “We found that maximum effectiveness was achieved by combining two agents: temozolomide, the chemotherapy most commonly used to treat patients with IDH mutant gliomas, with a drug that blocks PAR breakdown, known as a PAR glycohydrolase inhibitor.”

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